RESUMO
A case of suprasellar germinoma with subarachnoid seeding is presented. Patient had a history of depression unresponsive to drug therapy and recently developed diabetes insipidus. MR imaging revealed a huge suprasellar mass, heterogenous in signal intensity due to cystic components. MR spectroscopy of the mass showed prominent lipid peak suggesting high malignant potential.
Assuntos
Neoplasias Encefálicas/diagnóstico , Germinoma/diagnóstico , Imageamento por Ressonância Magnética/métodos , Invasividade Neoplásica/patologia , Tomografia Computadorizada de Emissão de Fóton Único/métodos , Adolescente , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/cirurgia , Seguimentos , Germinoma/diagnóstico por imagem , Germinoma/cirurgia , Humanos , Masculino , Medição de Risco , Sela Túrcica/patologia , Sensibilidade e Especificidade , Espaço Subaracnóideo/patologiaRESUMO
MR spectroscopy (MRS) of the brain in patients with multiple sclerosis has been well studied. However, in vivo MRS of the spinal cord in patients with MR spectroscopy has not been reported to our knowledge. We performed MRS of normal-appearing cervical spinal cords in multiple sclerosis patients and in healthy controls. N-acetyl aspartate was shown to be reduced within the cervical spinal cord of multiple sclerosis patients when compared with healthy controls. This finding supports axonal loss and damage within even normal-appearing spinal cords of multiple sclerosis patients.
Assuntos
Ácido Aspártico/análogos & derivados , Esclerose Múltipla/metabolismo , Medula Espinal/metabolismo , Adulto , Ácido Aspártico/metabolismo , Estudos de Casos e Controles , Vértebras Cervicais , Colina/metabolismo , Creatina/metabolismo , Feminino , Humanos , Inositol/metabolismo , Ácido Láctico/metabolismo , Metabolismo dos Lipídeos , Espectroscopia de Ressonância Magnética , Masculino , Esclerose Múltipla/patologia , Medula Espinal/patologiaRESUMO
PURPOSE: To test if the apparent diffusion coefficient (ADC) values reflect the ultrastructural changes of normal appearing white and gray matter with advancing age. MATERIALS AND METHODS: We selected 45 patients with normal MRI and DW imaging findings. DW and MRI imaging was performed and for each patient the average ADC on trace images of the frontal and occipital white matter and the thalamus were compared with increasing patient age. RESULTS: The average ADC value was 0.753+/-0.054 x 10-3 mm2/sec in frontal white matter, 0.673+/-0.085 x 10-3 mm2/sec in occipital white matter, and 0.763+/-0.063 x 10-3 mm2/sec in the thalamus. For white matter, ADC values increased with advancing age. Although ADC tended to increase with age, comparison of individual thalamic ADC and patient ages did not reach statistical significance. CONCLUSION: Advancing age is associated with a small but statistically significant increase of water diffusibility in human white matter. This increase may reflect mild structural changes with normal aging.
